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Anxiety Working Group Leadership

manuel mattheisen

Manuel Mattheisen, MD

Core Analytical Group

Co-Director

purves-kirstin-kclsgdp-2019-10-02-000381.xa27b4a70

Kirstin Purves, PhD

Core Analytical Group

Co-Director

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Silviu-Alin Bacanu, PhD

Core Analytical Group

Co-Director

rosa cheesman

Rosa Cheesman, PhD

Outreach Committee Liason

Work with us!

If you have questions regarding the PGC ANX workgroup or projects that are currently being conducted, please contact the workgroup chairs.

For any questions or ideas related to research dissemination (e.g., via this webpage, social media, blogs, press outlets), please contact the workgroup outreach liaison.

If you have questions about how to access summary statistics or genotype-level data, or are interested to submit a secondary analysis proposal, please contact the workgroup data access committee representative.

About Us

Our History

After an initial meeting of the chairs at the WCPG 2016 in Jerusalem, the PGC Anxiety Workgroup became part of the PGC in 2017 with a kick-off meeting during WCPG 2017 in Orlando. Since then, our membership has grown to include over 30 groups from about 10 countries.

Our Motivation

We are conducting genome-wide association studies (GWAS) based on statistically powerful samples of patients with anxiety disorders and healthy individuals with data on anxiety measures. Our long-term objective is to provide further insight into the pathophysiology and neurobiological underpinnings of anxiety disorders through the identification of genetic risk variants, leading to the development of novel treatments or biomarkers.

 

Our analyses will include GWAS in (i) categorical case-control samples (panic disorder, agoraphobia, generalized anxiety disorder, social phobia and specific phobia), (ii) population based samples with dimensional anxiety measures (e.g. GAD-7, STAI, ACQ, ASI), and (iii) samples with information on response to treatment for anxiety disorders. We are also keen to aid parallel GWAS consortium efforts (CAPICE, EAGLE) on the development of anxiety disorders in childhood and adolescence, and to contribute to post-genomic research on anxiety, capitalising on genome sequence and epigenetic data.

Get Involved!

We welcome anyone who is interested to join us. We are eager to collaborate with investigators who might be willing to share raw phenotypic/genotypic/other omic data or genetic effect sizes via summary statistics.

 

We welcome anyone who is interested to join us. For further information please contact the workgroup chairs Jürgen Deckert, Thalia Eley, and John (Jack) Hettema or email the group at pgcanx@kcl.ac.uk.

Publications

We are working on our first official PGC Anxiety publication – watch this space!

 

Influential anxiety GWAS publications involving members of our group:

 

Levey DF, Gelernter J, Polimanti R, et al.: Reproducible genetic risk loci for anxiety: results from ∼200,000 participants in the Million Veteran Program. Am J Psychiatry 2020; 177:223–232

 

Meier SM, Trontti K, Purves KL, et al.: Genetic variants associated with anxiety and stress-related disorders: a genome-wide association study and mouse-model study. JAMA Psychiatry 2019 22;76(9):924-932

 

Forstner AJ, Awasthi S, Wolf C, et al.: Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression. Mol Psychiatry 2019 https://doi.org/10.1038/s41380-019-0590-2

 

Purves, K.L., Coleman, J.R.I., Meier, S.M… et al.: A major role for common genetic variation in anxiety disorders. Molecular Psychiatry 2019. doi:10.1038/s41380-019-0559-1

 

Otowa T, Hek K, Lee M, et al.: Meta-analysis of genome-wide association studies of anxiety disorders. Mol Psychiatry 2016; 21:1485

 

Erhardt A, Akula N, Schumacher J, et al.: Replication and meta-analysis of TMEM132D gene variants in panic disorder. Transl Psychiatry 2012; 2:e156

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